Colobomatous cyst: Histopathological characterization

Introduction: colobomatous cyst is one of the rare orbital cystic lesions that have wide range of differential diagnosis. It is a congenital lesion that can be easily misdiagnosed as malignant tumor, leading to exposing the patient to unnecessarily overtreatment. case report: this is a rare case of congenital colobomatous cyst in an infant girl. the cyst was associated with a microphthalmic globe. radiologically, the cyst was located in the inferior half of the orbital cavity. surgical excision was performed and the histopathological examination demonstrated a collapsed cyst with smooth tan lining. the wall of the cyst had an inner neuroretinal layer and an outer fibrovascular layer. conclusion: Any orbital cystic lesion should not be diagnosed without the clinicopathological and radiopathological correlations, to avoid any histopathological over diagnosis of some benign cysts as a malignant one. the pathologic features of colobomatous cysts are rarely described in literature with only one article in the PubMed search discussing these features in some details. Abdullah Al-Khamiss1, Ayman Ayoubi2, Muhammad Manzoor3, Sadeq Al-Dandan1 Affiliations: 1Department of Pathology, King Fahad Medical City, Riyadh, Saudi Arabia; 2Department of Ophthalmology, King Fahad Medical City, Riyadh, Saudi Arabia; 3Department of Radiology, King Fahad Medical City, Riyadh, Saudi Arabia. Corresponding Author: Abdullah Saleh Al-Khamiss, Department of Pathology, King Fahad Medical City, Al-Olaya, Khurais road, Riyadh city, Riyadh region, Kingdom of Saudi Arabia; Ph: 00966-506-13-9201; E-mail: [email protected] Received: 30 May 2015 Accepted: 14 July 2015 Published: 07 October 2015